Correction: The effect of activated protein C on experimental acute necrotizing pancreatitis

Study Protocol After the stabilization period, 45 male rats were randomly divided into three groups. Rats in group I (control group; n = 15) underwent laparotomy with manipulation of the pancreas (sham procedure) and received 10 ml/kg saline intravenously (single dose). Groups II and III underwent laparotomy with induction of ANP. Rats in group II (positive control; n = 15) received saline, as in group I but 6 hours after induction of ANP. Rats in group III (treatment group; n = 15) received 100 μg/kg recombinant human APC (Drotrecogin alfa [activated]; Xigris; Lilly, Istanbul, Turkey) intravenously (single dose) 6 hours after induction of ANP. Twenty-four hours after induction of ANP, all surviving animals were killed by intracardiac infection of pentobarbital (200 mg/kg). Blood samples were taken from the heart before the animals were killed in order to measure serum amylase, TNF-α, and IL-6. Animals that died before the end of the study (four in group II and two in group III) were excluded from the analysis. References 1. Yamenel L, Mas MR, Comert B, Isik AT, Aydin S, Mas N, Deveci S, Ozyurt M, Tasci I, Unal T: The effect of activated protein C on experimental acute necrotizing pancreatitis. Crit Care 2005, 9:R184-R190. Correction Correction: The effect of activated protein C on experimental acute necrotizing pancreatitis Levent Yamanel1, Mehmet Refik Mas2, Bilgin Comert3, Ahmet Turan Isik4, Sezai Aydin5, Nuket Mas6, Salih Deveci7, Mustafa Ozyurt8, Ilker Tasci9 and Tahir Unal10